Part of the M1 was closed for several hours after a lorry carrying 44 tonnes of glass bottles overturned.
Highways England said the northbound carriageway reopened at about 11:00 BST following the crash between junction 38 and 39.
The lorry overturned after it collided with a car between the junctions for Haigh and Durkar in West Yorkshire in the early hours.
Police said the male driver of the car sustained minor injuries.
Highways England tweeted that drivers faced delays and diversions were in place.
It said there had been a substantial fuel spillage across the carriageway, with crews working through the night to clear the road.